×
Entrez Id:
27030
Gene Symbol:
MLH3
MLH3
0.500
Biomarker
group
CLINGEN
The first functional study of MLH3 mutations found in cancer patients.
18521850
2008
×
Entrez Id:
27030
Gene Symbol:
MLH3
MLH3
0.500
Biomarker
group
CLINGEN
Conditional nuclear localization of hMLH3 suggests a minor activity in mismatch repair and supports its role as a low-risk gene in HNPCC.
17203173
2007
×
Entrez Id:
27030
Gene Symbol:
MLH3
MLH3
0.500
Biomarker
group
CLINGEN
Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse.
16204034
2005
×
Entrez Id:
27030
Gene Symbol:
MLH3
MLH3
0.500
Biomarker
group
CLINGEN
Evidence that hMLH3 functions primarily in meiosis and in hMSH2-hMSH3 mismatch repair.
19483466
2009
×
Entrez Id:
27030
Gene Symbol:
MLH3
MLH3
0.500
Biomarker
group
CLINGEN
Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair.
16322221
2005
×
Entrez Id:
9156
Gene Symbol:
EXO1
EXO1
0.310
Biomarker
group
CLINGEN
Molecular characteristics of mismatch repair genes in sporadic colorectal tumors in Czech patients.
24484585
2014
×
Entrez Id:
9156
Gene Symbol:
EXO1
EXO1
0.310
Biomarker
group
CLINGEN
Identification of factors interacting with hMSH2 in the fetal liver utilizing the yeast two-hybrid system. In vivo interaction through the C-terminal domains of hEXO1 and hMSH2 and comparative expression analysis.
10856833
2000
×
Entrez Id:
9156
Gene Symbol:
EXO1
EXO1
0.310
Biomarker
group
CLINGEN
EXO1 variants occur commonly in normal population: evidence against a role in hereditary nonpolyposis colorectal cancer.
12517792
2003
×
Entrez Id:
9156
Gene Symbol:
EXO1
EXO1
0.310
Biomarker
group
CLINGEN
Functional alterations of human exonuclease 1 mutants identified in atypical hereditary nonpolyposis colorectal cancer syndrome.
12414623
2002
×
Entrez Id:
9156
Gene Symbol:
EXO1
EXO1
0.310
Biomarker
group
CLINGEN
HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes.
11429708
2001
×
Entrez Id:
9156
Gene Symbol:
EXO1
EXO1
0.310
Biomarker
group
CLINGEN
Tumor progression in Apc(1638N) mice with Exo1 and Fen1 deficiencies.
17452984
2007
×
Entrez Id:
1027
Gene Symbol:
CDKN1B
CDKN1B
0.300
Biomarker
group
CLINGEN
p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability.
17954563
2008
×
Entrez Id:
1027
Gene Symbol:
CDKN1B
CDKN1B
0.300
Biomarker
group
CLINGEN
Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases.
9736017
1998
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.300
Biomarker
group
CLINGEN
DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response.
16478982
2006
×
Entrez Id:
64218
Gene Symbol:
SEMA4A
SEMA4A
0.300
Biomarker
group
CLINGEN
Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis.
27476653
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.300
Biomarker
group
CLINGEN
The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.
18996005
2009
×
Entrez Id:
2052
Gene Symbol:
EPHX1
EPHX1
0.300
Biomarker
group
CLINGEN
Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer.
25058500
2015
×
Entrez Id:
79728
Gene Symbol:
PALB2
PALB2
0.300
Biomarker
group
CLINGEN
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.
27978560
2017
×
Entrez Id:
79728
Gene Symbol:
PALB2
PALB2
0.300
Biomarker
group
CLINGEN
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312
2016
×
Entrez Id:
11200
Gene Symbol:
CHEK2
CHEK2
0.300
Biomarker
group
CLINGEN
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells.
24976383
2014
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
0.300
Biomarker
group
CLINGEN
The depletion of ATM inhibits colon cancer proliferation and migration via B56γ2-mediated Chk1/p53/CD44 cascades.
28093285
2017
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
0.300
Biomarker
group
CLINGEN
Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients.
25368522
2014
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
0.300
Biomarker
group
CLINGEN
Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer.
28135145
2017
×
Entrez Id:
4437
Gene Symbol:
MSH3
MSH3
0.300
Biomarker
group
CLINGEN
Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis.
27476653
2016
×
Entrez Id:
472
Gene Symbol:
ATM
ATM
0.300
Biomarker
group
CLINGEN
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.
27978560
2017